Bioactive Small Molecules
Cayman Chemical (R,S)-N-Nitrosoanatabine, Purity: ≥98%, CAS: 887407-16-1, 5 mg
A tobacco-specific nitrosamine; not carcinogenic in rats at 1, 3, and 9 mmol/kg
Apexbio Technology LLC PHA-680632 398493-79-3 200mg
PHA-680632 (CAS 398493-79-3) is a small molecule inhibitor targeting Aurora kinases a family of serine/threonine kinases involved in the regulation of mitosis and chromosomal segregation It potently inhibits Aurora A B and C kinases with IC50 values of 27 nM 135 nM and 120 nM respectively PHA-680632 demonstrates considerably less activity against other kinases such as FGFR1 FLT3 LCK PLK1 STLK2 VEGFR2 and VEGFR3 (IC50 390 5500 nM) In cellular assays PHA-680632 suppresses the proliferation of various cancer cell lines including HCT116 A2780 HL60 and HeLa with IC50 values ranging from 0 06 to 7 15 M This compound serves as a valuable tool for investigating Aurora kinase function and evaluating therapeutic strategies targeting mitotic regulation in cancer research
Medchemexpress LLC HY-16658B 10mg , Z-VAD-FMK CAS:161401-82-7 Purity:>98%
HY-16658B 10mg Z-VAD-FMK CAS: 161401-82-7 Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC 7-TFA-ap-7-Deaza-dG | 666847-77-4 | 98.0% | 415.32 | 10 MM / 1 ML
7-TFA-ap-7-Deaza-dG is a modified nucleoside and a click chemistry reagent. It contains an alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules containing azide groups.
- Modified nucleoside
- Click chemistry reagent
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAC)
- Used in DNA/RNA synthesis
- Functions as a nucleoside antimetabolite/analog
Medchemexpress LLC Rupintrivir | 223537-30-2 | 99.9% | 598.66 g·mol⁻¹ | C31H39FN4O7 | 25 MG
Rupintrivir is a potent, selective, irreversible inhibitor of human rhinovirus (HRV) 3C protease provided as a research-grade small molecule for antiviral and protease inhibition studies.
- Potent, selective, irreversible inhibition of HRV 3C protease.
- High purity suitable for biochemical and cellular assays.
- Molecular weight 598.66 g·mol⁻¹; chemical formula C31H39FN4O7.
- Available in small powder quantities for research use.
- Soluble in common organic solvents for stock preparation.
Cayman Chemical Lipid HTO12, Purity: ≥98%, CAS: 3047222-45-4, 5 mg
An ionizable cationic lipid (pKa = 6.432); has been used in combination with other lipids in the formation of LNPs for the delivery of mRNA in vitro and in vivo; LNPs containing lipid HTO12 and encapsulating adenine base editor mRNA targeting Pcsk9 reduce hepatic Pcsk9 levels in mice at a reduced ionizable lipid/total lipids-to-mRNA ratio than LNPs containing SM-102
Medchemexpress LLC COH-SR4 | 73439-19-7 | 99.5% | 350.03 g/mol | C13H8Cl4N2O | 50MG
COH-SR4 is a small-molecule AMP-activated protein kinase (AMPK) activator used in preclinical research. It exhibits reported anti-proliferative activity against several cancer cell lines and can inhibit adipocyte differentiation via AMPK activation. Supplied as a high-purity powder for laboratory research and intended for investigational use only.
- High purity (99.5%) verified by supplier.
- Known AMPK activation and anti-proliferative activity in vitro.
- Available in multiple pack sizes to support various study scales.
- Stable under recommended storage conditions for extended shelf life.
- Suitable for cancer and metabolic disorder research applications.
Medchemexpress LLC IR-783 (ADS 780WS) | 115970-66-6 | 99.9% | 749.35 | 1 ML
IR-783 (ADS 780WS) is a near-infrared (NIR) heptamethine cyanine fluorescent probe that significantly inhibits tumor growth and induces apoptosis in the MDA-MB-231 xenograft model. It is suitable for breast cancer research.
- Functions as a near-infrared heptamethine cyanine fluorescent probe.
- Demonstrates significant inhibition of tumor growth.
- Induces apoptosis in a xenograft model.
- Useful for breast cancer studies.
Medchemexpress LLC Protac errα degrader-3 | 2306388-65-6 | 98.8% | 956.99 | 10 MM * 1 ML
PROTAC ERRα Degrader-3 is a potent and selective ERRα degrader based on von Hippel-Lindau ligand, capable of specifically degrading ERRα protein by >80% at 30 nM and is inactive against ERRβ and ERRγ proteins.
- Dose-dependently induces ERRα degradation.
- Decreases protein levels of ERRα downstream target genes.
- Exhibits an IC50 value of 12.67 nM to block protein-protein interaction of ERRα with PGC-1α peptide.
Medchemexpress LLC H-D-Phe(2-Cl)-OH | 80126-50-7 | 99.9% | 199.63 | 5 G
H-D-Phe(2-Cl)-OH is a phenylalanine derivative, recognized as a beneficial ergogenic dietary substance. It is commercially used as an ergogenic supplement, influencing anabolic hormones, fuel supply during exercise, mental performance under stress, and preventing exercise-induced muscle damage.
- Designed for research use only
- Influences anabolic hormone secretion
- Assists with fuel supply during exercise
- Enhances mental performance during stress-related tasks
- Prevents exercise-induced muscle damage
Cayman Chemical C-82, Purity: ≥98%, CAS: 1422253-37-9, 1 mg
A β-catenin/CBP inhibitor and active metabolite of PRI-724; reduces the proliferation and protein levels of cyclin D1, α-smooth muscle actin (α-Sma), and Ki-67, a marker of cell proliferation, in primary mouse HSCs at 10 µM; decreases viability in continuous culture-activated primary mouse HSCs at 10 µM; induces apoptosis in non-stem- and stem cell subpopulations of tyrosine kinase inhibitor-resistant, patient-derived, and blast crisis phase CML cells with or without co-culture of primary human bone marrow MSCs in combination with nilotinib
Cayman Chemical PF-05190457, Purity: ≥95%, CAS: 1334782-79-4, 5 mg
An inverse agonist of GHS-R; selectively binds to GHS-R (Ki = 4.37 nM) over M2 mAChRs (Ki = 1,950 nM) and 5-HT2B receptors (IC50 = 3,700 nM); increases glucose-induced insulin secretion in primary human pancreatic islets at 1 µM; potentiates GLP-1-induced intracellular calcium levels in isolated dispersed rat islets at 100 nM; increases ex vivo vagal nerve firing rate in rats when administered intragastrically (EC50 = 10.7 nM)
![Medchemexpress LLC 4-[(4,5-dihydro-3-isoxazolyl)oxy]-N,N,N-trimethyl-2-butyn-1-aminium iodide | 247079-84-1 | 99.5% | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230407.png-250.jpg)
Medchemexpress LLC 4-[(4,5-dihydro-3-isoxazolyl)oxy]-N,N,N-trimethyl-2-butyn-1-aminium iodide | 247079-84-1 | 99.5% | 1 ML
Iperoxo is a potent muscarinic acetylcholine receptor (mAChR) superagonist provided for research use, supplied as a 10 mM solution in DMSO and in solid quantities for in vitro pharmacology and receptor activation studies.
- Potent mAChR superagonist for receptor activation studies.
- Provided as 10 mM solution in DMSO, 1 mL vial.
- High purity (≈99.5%) suitable for biochemical assays.
- Molecular formula C10H17IN2O2; molecular weight 324.16 g/mol.
- Available as solid quantities for formulation flexibility.
![Medchemexpress LLC 2,7-bis(3-morpholinopropyl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzo[lmn][3,8]phenanthroline | 2101208-44-8 | 98.2% | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230289.png-250.jpg)
Medchemexpress LLC 2,7-bis(3-morpholinopropyl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzo[lmn][3,8]phenanthroline | 2101208-44-8 | 98.2% | 50 MG
CM03 is a small-molecule G-quadruplex (G4) DNA ligand that binds and stabilizes G4 structures, downregulates G4-containing genes, and increases double-strand break events. It has demonstrated selective potency in pancreatic cancer cell models and is supplied for research use only.
- Binds and stabilizes DNA G-quadruplex structures.
- Downregulates expression of G4-containing genes.
- Increases incidence of double-strand DNA breaks due to torsional strain.
- Molecular formula C34H44N6O6; molecular weight 632.75 g/mol.
- High purity suitable for research applications.
- Intended for research use only; not for human use.
Selleck Chemical LLC Cryptotanshinone 10mg 35825-57-1
Cryptotanshinone is a STAT3 inhibitor with IC50 of 4.6 ?M in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5. Cryptotanshinone induces ROS-dependent autophagy and mitochondria-mediated apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.